Protein secondary structure prediction using sigmoid belief networks to parameterize segmental semi-Markov models

In this paper, we merge the parametric structure of neural networks into a segmental semi-Markov model to set up a Bayesian framework for protein structure prediction. The parametric model, which can also be regarded as an extension of a sigmoid belief network, captures the underlying dependency in residue sequences. The results of numerical experiments indicate the usefulness of this approach.